PheLiM
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This is the supporting website for the publication:
"Quantitative estimation of gene-to-phenotype contributions from genome-wide siRNA screens."
PheLiM (Phenotypic Linear Model) integrates predictions of off- and on-target siRNA-induced down-regulation to infer gene-specific contributions to phenotypes that are measured in RNA interference screens. The inference of phenotype-critical genes from siRNA-based screens is challenging, due to pervasive off-target effects of siRNAs. Combining state-of-the-art off-target predictions with predictions of relative on-target efficacy of siRNAs, PheLiM estimates quantitatively the contribution of individual genes to the phenotypes measured through siRNA screening. |